1987年李蓬从北京师范大学毕业；1988年获得中美CUSBEA奖学金留学美国；1995年获得加州大学圣地亚哥分校博士学位，随后在新加坡国立大学分子与细胞生物学研究所、美国达拉斯西南医学中心，霍华德休斯医学研究所进行博士后研究；1997年应聘在新加坡分子和细胞生物学研究所任研究室主任和助理教授；2003年任香港科技大学生物系研究室主任、助理教授；2006年全职回国任清华大学生物科学与技术系教授；2009年起任清华大学生命科学学院副院长；2012年获得何梁何利基金科学与技术进步奖；2015年12月当选中国科学院院士；2016年11月当选为发展中国家科学院院士；2017年获得第二届叶剑英奖。
个人荣誉：
2016年 当选发展中国家科学院（TWAS）院士
2015年 当选中国科学院院士
2012年 何梁何利基金生命科学领域科学与技术进步奖
2009年 国家杰出青年基金资助
2008年 亚太分子生物学网络第一届阿瑟·科恩伯格纪念讲演奖（Arthur Kornberg Memorial Lecture award）
1999年 新加坡青年科学家奖
主要研究脂代谢调控的分子机制，脂滴的形成、融合、动态变化及与内质网、线粒体等细胞器的相互作用，以及肥胖、糖尿病、脂肪肝等代谢性疾病的发生和发展机制。
34. Zhineng Chen, Shuai Zhao, Kai Hu, Jing Han, Yuan Ji, Shaoping Ling, Xieping Gao, A hierarchical and multi-view registration of serial histopathological images. , Pattern Recognition Letters. 2021, 152: 210-217. 查看PDF
33. Huanhuan Pang , Yisheng Jiang , Jie Li , Yushen Wang , Meng Nie, Nan Xiao, Shuo Wang, Zhihong Song, Fansen Ji, Yafei Chang, Yu Zheng, Ke Yao, LiAng Yao, Shao Li, Peng Li, Lei Song, Xun Lan, Zhiheng Xu, Zeping Hu*, Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly, Nature Metabolism, 2021, 3(8): 1109-1124 查看PDF
32. Meng Nie, Ke Yao, Xinsheng Zh, Na Chen Nan Xiao, Yi Wang, Bo Peng, LiAng Yao, Peng Li, Peng Zhang, Zeping Hu*, Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma, Nature communications, 2021, 12(1): 1-13. 查看PDF
31. Fengsheng Li , Jia Song, Yingkun Zhan, Shuaikang Wang, Jinhui Wang, Li Lin, Chaoyong Yang , Peng Li, He Huang*, LINT‐Web: A Web‐Based Lipidomic Data Mining Tool Using Intra‐Omic Integrative Correlation Strategy, Small Methods, 2021, 5(9): 2100206. 查看PDF
30. Lyu X.1, Wang J.1, Wang J.1, Yin Y., Zhu Y., Li L.-L., Huang S., Peng S., Xue B., Liao R., Wang S.-Q., Long M., Wohland T., Chua B.T., Sun Y., Li P., Chen X.-W., Xu L., Chen F.-J.*, and Li P.*., A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion, Developmental Cell, 2021, 56(18): 2592-2606. e7. 查看PDF
29. Chen X W#, Ding G#, Xu L, Li P*, A glimpse at the metabolic research in China, Cell Metab 33: 2122-2125 查看PDF
28. Jing Gong Kui Xu , Ziyuan Ma, Zhi John Lu and Qiangfeng Cliff Zhang *, A deep learning method for recovering missing signals in transcriptome-wide RNA structure profiles from probing experiments, Nature Machine Intelligence, 2021, 3(11): 995-1006. 查看PDF
27. Xu Wang , ao-Yan Wang, Guo-Sheng Hu , Wen-Shuai Tang , Li Weng, Yuzhu Zhang, Huiling Guo, Shan-Shan Yao, Shen-Ying Liu, Guo-Liang Zhang, Yan Han, Min Liu, Xiao-Dong Zhang, Xiang Cen, Hai-Feng Shen, Nengming Xiao, Chang-Qin Li, Hong-Rui Wang, Jing Huang, Wen Liu, Peng Li , Tong-Jin Zhao*, DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity, Cell Reports, 2021, 35(12): 109281. 查看PDF
26. Wen-Shuai Tang, Li Weng, Xu Wang, Chang-Qin Liu, Guo-Sheng Hu, Shu-Ting Yin, Ying Ta, Ni-Na Hong, Huiling Guo, Wen Liu, Hong-Rui Wang, Tong-Jin Zhao* , The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity, Cell Reports, 2021, 36(1): 109314. 查看PDF
25. Lei Xiong, Kang Tian, Yuzhe Li , Weixi Ning , Xin Gao, Qiangfeng Cliff Zhang* , Online single-cell data integration through projecting heterogeneous datasets into a common cell-embedding space, Nat Commun. 2022 查看PDF
24. 刘叶阳 | 许梦瑶 | 李蓬 | 黄勋 | 徐俐, 脂滴与其他细胞器互作调控脂稳态的分子机制, 中国科学: 生命科学52: 76–94 查看PDF
23. Tang G.1, Ma C.1, Li L., Zhang S., Li F., Wu J., Yin Y., Zhu Q., Liang Y., Wang R., Huang H., Zhao T.-J., Yang H., Li P., and Chen F.-J.*, PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure, SCIENCE CHINA-Life Sciences, 2022, 65(11): 2287-2300 查看PDF
22. Wenmin Wang, Jizheng Wang, Ke Yao, Shuiyun Wang, Meng Nie, Yizi Zhao, Bohong Wang, Huanhuan Pang, Jingjing Xu, Guixin Wu, Minjie Lu, Nan Tang, Chunmei Qi, Hengzhi Pei, Xufang Luo, Dongsheng Li, Tianshu Yang, Qing Sun, Xiang Wei, Yan Li, Dingsheng Jiang, Peng Li, Lei Song , Zeping Hu*, Metabolic characterization of hypertrophic cardiomyopathy in human heart. , Nature Cardiovascular Research 查看PDF
21. Xu Wang, Shen-Ying Liu, Guo-Sheng Hu, Hao-Yan Wang, Guo-Liang Zhang, Xiang Cen, Si-Ting Xiang, Wen Liu, Peng Li, Haobin Ye, Tong-Jin Zhao, DDB1 prepares brown adipocytes for cold-induced thermogenesis, Life Metabolism 查看PDF
20. Guo H#, Wang J#, Ren S#, Zheng LF#, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ*, Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system, Nature Communications, 13:6004 查看PDF
19. Ronghui You, Wei Qu, Hiroshi Mamitsuka, Shanfeng Zhu*, DeepMHCII: a novel binding core-aware deep interaction model for accurate MHC-II peptide binding affinity prediction, Bioinformatics (Intelligent Systems for Molecular Biology 2022 ) 查看PDF
18. Xuan Shen 1, Yajun Zhang 1, Xuetao Ji 1, Bo Li 1, Yuzhu Wang 1, Yun Huang 1, Xu Zhang 1, Jingxian Yu 1, Ruihan Zou 1, Dongdong Qin 2, Hongwen Zhou 3, Qian Wang 1, John Zhong Li 1 4, Long Noncoding RNA lncRHL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis, Diabetes. 2022 Sep 1;71(9):1915-1928. doi: 10.2337/db21-1145. 查看PDF
17. Rong Li, Michela Colombo, Guanlin Wang, Sally-Ann Clark, Antonio Rodriguez-Romera, Yiran Meng, Abdullah Khan, Wei Xiong Wen, Nikolaos Sousos, Lauren Murphy, Christina Simoglou Karali, Korsuk Sirinukunwattana, Jennifer O'Sullivan, Ruggiero Norfo, Qian Cheng, Charlotte Brierley, Joana Carrelha, Zemin Ren, Gabriel A. Rabinovich, Vijay A Rathinam, Supat Thongjuea, Daniel Royston, Adam J Mead, Bethan Psaila, Cross-Talk between Hematopoietic Cells and Fibroblast Subsets Drives Inflammation and Remodelling of the Bone Marrow Microenvironment in Myeloproliferative Neoplasms, Blood (美国血液学大会会议论文) 查看PDF
16. Zhineng Chen, Jing Wang, Caiyan Jia*, Xiongjun Ye,, Pathological image super resolution using mix attention generative adversarial network, International Journal of Machine Learning and Cybernetics 查看PDF
15. Xinyue Wu, Zhineng Chen, Changgen Peng*, Xiongjun Ye*, MMSRNet: Pathological image super-resolution by multi-task and multi-scale learning, Biomedical Signal Processing and Control, vol. 81, 104428:1-11, 2023 查看PDF
14. Kexin Sun, Zhineng Chen*, Gongwei Wang, Jun Liu, Xiongjun Ye, Yu-Gang Jiang, Bi-directional Feature Fusion Generative Adversarial Network for Ultra-high Resolution Pathological Image Virtual Re-staining, IEEE Conference on Computer Vision and Pattern Recognition (CVPR’23), Vancouver, Canada 查看PDF
13. Jiaming Liu1,2,3#, Liangkui Li1#, Dijin Xu1, Yuqi Li1, Tao Chen4, Yeyang Liu1, Yuqian Bao5, Yan Wang6,7, Longyan Yang6,7, Peng Li1,2,3*, Li Xu1,2*, Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorder, SCIENCE CHINA Life Sciences 查看PDF
12. Muzhi Dai, Zhuoer Dong, Kui Xu, Qiangfeng Cliff Zhang*, CryoRes: Local Resolution Estimation of Cryo-EM Density Maps by Deep Learning,
Journal of Molecular Biology 查看PDF
11. Weiqi Zhai , Xiaodi Huang , Nan Shen Shanfeng Zhu*, Phen2Disease: a phenotype-driven model for disease and gene prioritization by bidirectional maximum matching semantic similarities, Brief Bioinform. 2023 May 29;bbad172. doi: 10.1093/bib/bbad172. 查看PDF
10. Shaojun Wang , Ronghui You, Yunjia Liu, Yi Xiong, Shanfeng Zhu*, NetGO 3.0: Protein Language Model Improves Large-scale Functional Annotations, Genomics Proteomics Bioinformatics. 2023 Apr 17;S1672-0229(23)00066-9. doi: 10.1016/j.gpb.2023.04.001 查看PDF
9. Ziye Wang, Pingqin Huang , Ronghui You, Fengzhu Sun Shanfeng Zhu* , MetaBinner: a high-performance and stand-alone ensemble binning method to recover individual genomes from complex microbial communities, Genome Biol. 2023 Jan 6;24(1):1. doi: 10.1186/s13059-022-02832-6. 查看PDF
8. Zhirui Liao , Lei Xie , Hiroshi Mamitsuka , Shanfeng Zhu*, Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer, Bioinformatics. 2023 Jan 1;39(1):btac814. doi: 10.1093/bioinformatics/btac814. 查看PDF
7. Baowen Yu, Moran Hu, Wanzi Jiang, Yizhe Ma, Jingya Ye, Qinyi Wu, Wen Guo, Yan Sun, Min Zhou, Yiwen Xu, Zhoulu Wu, Yiwen Wang, Sin Man Lam, Guanghou Shui, Jingyu Gu, John Zhong Li, Zhenzhen Fu, Yingyun Gong, Hongwen Zhou, Ceramide d18:1/24:1 as a potential biomarker to differentiate obesity subtypes with unfavorable health outcomes, Lipids in Health and dieases 查看PDF
6. Yingyun Gong, Qinyi Wu, Shushu Huang, Zhenzhen Fu, Jingya Ye, Ruiping Liu, Shibo Lin, Wei Guan, Ningli Yang, John Zhong Li, Hui Liang, Hongwen Zhou, Functional Characterization of MC4R Variants in Chinese Morbid Obese Patients and Weight Loss after Bariatric Surgery, Advanced Biology 查看PDF
5. Wang, Chen；Yu, Leiye；Zhang, Jiying；Zhou, Yanxia；Sun, Bo；Xiao, Qingjie；Zhang, Minhua；Liu, Huayi；Li, Jinhong；Li, Jialu；Luo, Yunzi；Xu, Jie；Lian, Zhong；Lin, Jingwen；Wang, Xiang；Zhang, Peng；Guo, Li；Ren, Ruobing；Deng, Dong, Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1, Nature Communications 查看PDF
4. Yu, Tianshi；Huang, Tianyang；Yu, Leiye；Nantasenamat, Chanin；Anuwongcharoen, Nuttapat；Piacham, Theeraphon；Ren, Ruobing；Chiang, Ying-Chih, Exploring the Chemical Space of CYP17A1 Inhibitors Using Cheminformatics and Machine Learning, Molecules 查看PDF
3. Wu, XiaomeiPang, BinYou, Jianwei; Yu, Leiye; Ren, Ruobing; Wang, Hongyang; Chen, Li, An LC-MS-based workflow measures the export activity of S1P transporters., Biochemical and Biophysical Research Communications 查看PDF
2. Zeshuai Wang#, Zhisheng Wu#, Hao Wang#, Ruoqing Feng#, Guanlin Wang#,*, Muxi Li#, Shuang-Yin Wang#, Xiaoyan Chen#, Yiyi Su, Jun Wang, Weiwen Zhang, Yuzhou Bao, Zhenwei Lan, Zhuo Song, Yiheng Wang, Xianyang Luo, Lingyu Zhao, Anli Hou, Shuye Tian, Hongliang Gao, Wenbin Miao, Yingyu Liu, Huilin Wang, Cui Yin, Zhi-Liang Ji, Mingqian Feng, Hongkun Liu, Lianghui Diao, Ido Amit, Yun Chen, Yong Zeng, Florent Ginhoux*, Xueqing Wu*, Yuanfang Zhu*, Hanjie Li*, An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development, Cell 查看PDF
1. Rong Li, View ORCID ProfileMichela Colombo, Guanlin Wang, Antonio Rodriguez-Romera, Jennifer O’Sullivan, Sally-Ann Clark, Juan M. Pérez Sáez, Yiran Meng, Abdullah O. Khan, Sean Wen, Pengwei Dong, Wenjiang Zhou, Nikolaos Sousos, Lauren Murphy, Matthew Clarke, Natalie J. Jooss, Aude-Anais Olijnik, Zoë C. Wong, Christina Simoglou Karali, Korsuk Sirinukunwattana, View ORCID ProfileHosuk Ryou, Ruggiero Norfo, Qian Cheng, Charlotte K. Brierley, Joana Carrelha, Zemin Ren, Supat Thongjuea, Vijay A Rathinam, View ORCID ProfileAnandi Krishnan, View ORCID ProfileDaniel Royston, Gabriel A. Rabinovich, View ORCID ProfileAdam J Mead, View ORCID ProfileBethan Psaila, A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis., bioRxiv(also under revision in Science Translational Medicine) 查看PDF
